Leprosy disease remains an important public health issue as it is still endemic in several countries.Mycobacterium leprae, the causative agent of leprosy, presents tropism for cells of the reticuloendothelial and peripheral nervous system.Current multidrug therapy consists of cowboys ps5 controller clofazimine, dapsone and rifampicin.Despite signif
Abstract Background The deubiquitinase (DUB) family constitutes a group of proteases that regulate the stability or reverse the ubiquitination of many proteins in the cell.These enzymes participate in cell-cycle regulation, cell division and differentiation, diverse physiological activities such as DNA damage repair, growth and development, and res
Oncolytic virotherapy has shown impressive results in preclinical studies and first promising therapeutic outcomes in clinical trials as well.Since viruses are known for a long time as excellent vaccination agents, oncolytic viruses are the gel bottle audrey now designed as novel anticancer agents combining the aspect of lysis-dependent cytoreducti
Activity recognition, a key component in pervasive healthcare monitoring, relies on classification algorithms that require labeled data of individuals performing the activity of interest to train accurate models.Labeling data can be performed in a lab setting where an individual enacts the activity under controlled conditions.The ubiquity of mobile